For the St. Louis metro area (including counties like St. Louis, St. Charles, Jefferson, and parts of Illinois), effective paid advertising typically combines several approaches. Geotargeting is essential, with most agencies setting primary radiuses around 30-50 miles from downtown while creating micro-campaigns for distinct neighborhoods (Clayton for professionals, The Hill for traditional demographics, etc.). Google and Facebook/Instagram remain the primary platforms, but St. Louis shows higher-than-average engagement with YouTube and LinkedIn (particularly for targeting the healthcare, aerospace, and financial sectors). For B2B companies, targeting the 'Cortex Innovation Community' and the T-REX technology district yields strong results. Local agencies also leverage Cardinals and Blues game schedules for timing promotions, as the city shows significant engagement fluctuations around major sporting events. The most sophisticated St. Louis agencies incorporate cross-river strategies that acknowledge the different demographics between Missouri and Illinois sides of the metro area.