The 16 Best Programmatic Advertising Agencies in 2025

CIENCE Technologies is a distinguished digital marketing agency that fuses human expertise with advanced AI in B2B lead generation and sales support. Utilizing their proprietary CIENCE GO Platform, they drive revenue growth and enhance client expansion. Their CIENCE Outbound approach guarantees consistent engagement through tailored multi-channel outreach and enriched Prospect Experiences. Their innovative people-as-a-service (PaaS) model delivers optimal outcomes efficiently. Celebrated among the INC 5000 fastest-growing private companies for four years running.

Dragon360 is a premier digital marketing agency that propels brand growth across industries with a people-centric approach. They specialize in strategic insights, creative content, and integrated advertising, all underpinned by robust data analysis. As a Google Partner, they excel in crafting demand-generating strategies, engaging buyers, and driving cross-functional collaboration.

Media Matters Worldwide, a women-led agency since 2005, excels in media strategy, planning, buying, and analytics. Renowned for its expert team and cutting-edge media tech, MMWW offers bespoke, transparent, and results-oriented media solutions across diverse platforms, serving B2C and B2B clients with precision and innovation.

Fetch & Funnel excels as a full-funnel digital marketing agency with a niche in e-commerce, lead generation, and law firm marketing. Renowned for its prowess in paid and programmatic advertising, CRO, and impactful creative services, the agency has catalyzed over $500 million in client sales since 2017. Their tailored strategies, continuous optimization, and deep understanding of client objectives underscore their unique approach to driving substantial business growth.

Fifty & Five excels in shaping consumer interactions and sparking digital conversations via immersive social experiences. Our expertise spans digital and social media marketing, strategic planning, content creation, customer engagement, and sophisticated social monitoring. We serve diverse brands, from local to international, delivering insightful analytics and committing to meaningful projects starting at $5,000.

Effective Marketing stands out as a premier full-service paid media agency, blending big agency expertise with the nimbleness and affordability of a boutique team. With a remarkable $1 billion in media buying and a distinctive 0% commission model, they excel in crafting data-driven, accountable marketing strategies for B2B and B2C clients. Their proprietary systems for budgeting, conversion, partner vetting, and reporting ensure enhanced brand engagement and measurable business outcomes.

UnboundB2B is a digital marketing agency excelling in B2B demand generation, focusing on precision engagement and revenue growth. They specialize in Account-Based Marketing, high-quality lead generation, and pipeline acceleration. Leveraging a global network and advanced intent data analysis, they ensure a seamless transition from marketing to sales, backed by industry endorsements.

Nvent Marketing, a leading Phoenix-based digital marketing agency, excels in demand generation and strategic brand growth. Renowned for blending inbound and outbound tactics, including SEO, content marketing, paid media, and direct marketing, the agency thrives on transparency, innovation, and a customer-centric approach. Their comprehensive services, from website design to marketing automation, set them apart in the dynamic marketing industry.

Megethos, a distinguished digital marketing agency, excels in strategic PPC services, offering free audits and boasting expertise in Healthcare, Ecommerce, and Education sectors. With a 95% retention rate since 2017 and managing over $40M in ad spend, they specialize in paid media management, creative ad design, and CRO, delivering growth, transparent reporting, and clear ROI.

Corkboard Concepts distinguishes itself as a data-driven digital marketing agency, harnessing artificial intelligence to craft high-performing campaigns. Prioritizing strategic planning and creativity, they deliver personalized, results-focused services, ensuring their success is intertwined with their partners'. Their expertise spans from enhancing online visibility to targeted programmatic advertising, all grounded in robust data analytics.

EXL Media, since 1994, blends big agency expertise with boutique service, specializing in strategic media planning and buying. They excel in navigating modern media's complexities to optimize campaigns, ensuring impactful delivery of clients' messages. Their commitment to transparency, performance management, and industry innovation drives exceptional results, distinguishing them in the digital marketing landscape.

Nativz, known as "The Army of Nerds," is a Dallas-based digital marketing powerhouse specializing in elevating online presence. With a comprehensive suite of services from advanced branding design to robust web and app development, they excel in crafting impactful paid media campaigns and harnessing analytics for sustained success. Their proven track record across diverse industries, including high-profile clients, underscores their commitment to innovation and results-driven strategies for digital excellence.

ARSENL, a Miami-based digital marketing agency, excels in omnichannel advertising solutions that drive customer acquisition and brand scaling. Their expertise spans targeted digital campaigns, paid social, search, display, programmatic OTT, and creative asset development. As Google and Facebook Marketing partners, they deliver cohesive campaigns and robust e-commerce platforms, fostering engaged communities and impactful brand presence.

MuteSix stands out as a premier digital marketing agency, renowned for driving over $1.2 billion in direct revenue and mastering real-time performance marketing. With a track record of elevating brands through custom omnichannel strategies and award-winning creative content, the agency excels in delivering a 50% revenue boost on Meta and significant ROAS increases on platforms like Amazon. Their agile approach, "The M6Difference," combines advanced analytics, rapid market delivery, and holistic measurement to optimize client growth and market leadership.